Nanofiber-electrode cartridge for high-viability primary cell
This technology improves the process of getting drugs, genes, or other molecules into cells by combining two tools: a structured mat of tiny polymer fibers and a precisely controlled electric field. When cells sit on this fiber mat, their shape and internal mechanics change in ways that make their outer membranes more receptive to letting things in. By adjusting the direction and voltage of the electric current, researchers can tune how open the cell membrane becomes, making it easier to deliver payloads while keeping more cells alive than conventional electroporation methods. The approach appears especially valuable for rare or hard-to-transfect primary cells, which are notoriously difficult to work with.
What you could build
A research instrument or consumable cartridge—combining a nanofiber substrate with integrated electrodes—sold to cell therapy manufacturers and gene therapy labs that need to transfect primary T-cells, stem cells, or other rare cell types without unacceptable cell death.
Who in Virginia should care
Cell therapy and gene therapy contract manufacturers or CROs in the Virginia/Maryland/DC corridor, as well as Virginia-based university spin-outs working in immunotherapy or regenerative medicine.
Readiness: Lab validated
Concept — described but not yet demonstrated. Lab validated — supported by experimental results in the patent. Prototype likely — the text describes a built, working embodiment.
Readiness is inferred from the patent text, not from a lab visit.
The record
- Inventors
- Rafael DAVALOS, Amrinder NAIN
- Filed
- Patent pending — filed February 25, 2022
- Status
- Application
- Publication number
- US20220290183A1
Ready to talk?
Virginia Tech Intellectual Properties handles licensing for this technology.
Prosim summaries are generated from public patent text and are not legal advice.