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During intracavitary brachytherapy, healthy organs sitting too close to the radiation source receive damaging doses that cause serious side effects.

Older mitochondrial uncoupling agents could not distinguish between mitochondrial and plasma membranes, making them too toxic for clinical use despite proven metabolic benefits.

Organizations cannot reliably detect malicious or negligent insiders because rule-based security tools generate too many false alarms and miss subtle behavioral drift.

Riders and buyers have no reliable, standardized way to compare equestrian helmets on actual concussion protection.

Trace chemical detectors often fail or produce false negatives because target compounds are too dilute in ambient air to trigger a reliable signal.

Modern data center and AI hardware demands enormous power in shrinking physical spaces, and conventional transformer-based power converters are too bulky to keep pace.