Peak-preserving fluorescence baseline correction for Raman
This technology is a new mathematical algorithm called ISREA that cleans up Raman spectroscopy data by removing unwanted background noise—specifically the fluorescence and scattered light that obscure the real chemical signals. Traditional cleanup methods often accidentally erase or distort the very peaks they are supposed to preserve; ISREA avoids this by using flexible curve-fitting and an iterative error-correction loop that keeps meaningful peaks intact. The result is faster, more accurate spectral data that can then be used to identify or measure specific substances in a sample. The patent specifically demonstrates its value for analyzing dialysate fluid, suggesting a near-term application in kidney disease monitoring.
What you could build
A software module or embedded algorithm licensed to Raman spectroscopy instrument makers or clinical diagnostics companies to improve the accuracy of their existing hardware, particularly for non-invasive or fluid-based medical diagnostics such as kidney dialysis monitoring.
Who in Virginia should care
Medical device and clinical diagnostics companies in the Northern Virginia/DC corridor, or life sciences instrument firms with R&D presence in Virginia, would be plausible partners or licensees.
Readiness: Lab validated
Concept — described but not yet demonstrated. Lab validated — supported by experimental results in the patent. Prototype likely — the text describes a built, working embodiment.
Readiness is inferred from the patent text, not from a lab visit.
The record
- Inventors
- Ryan Senger, Pang Du, John L. Robertson, Yunnan Xu
- Filed
- Patent pending — filed March 1, 2021
- Status
- Application
- Publication number
- US20210270742A1
Ready to talk?
Virginia Tech Intellectual Properties handles licensing for this technology.
Prosim summaries are generated from public patent text and are not legal advice.